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A first editon of Jenner's "An Inquiry into the Causes and Effects of the Variolae Vaccinae", the monumental book of his career where he documents the use of cowpox to protect agains smallpox.

Letter from Edward Jenner to Col Brisbane on vaccine inoculation.

“Dr Jenner presents compliments to Col. Brisbane and has enclosed one of Mr Creaser’s papers on the mode of conducting the process of vaccine inoculation. It contains information that may prove [especially] useful to those practitioners who have not had it in their power to obtain a correct knowledge of it.”